Photodynamic therapy for airway stenosis in rabbit models.

Abstract

BACKGROUND:

Acquired airway stenosis in childhood is resistant to conventional treatment. We examined whether endoscope-assisted photodynamic therapy (PDT) is effective for airway stenosis in animal models of which the pathophysiologic progressions are similar to those of clinical cases showing rapid deterioration.

METHODS:

Tracheal mucosa-scraped rabbits were administered IV porfimer sodium (Photofrin; Wyeth K.K., Tokyo, Japan) [2 mg/kg], and the tracheal lesions were irradiated with 630 nm of light emitted from a cylindrical diffuser tip via a transtracheal approach.

RESULTS:

Rabbits without PDT (untreated animals) showed dense granulation tissue in the scraped lesion, resulting in airway stenosis complicated with respiratory stridor. PDT ameliorated the degree of airway stenosis (p = 0.008) and reduced respiratory stridor; rabbits that received PDT showed patchy granulation tissue that was only 20 to 30% of the volume of that seen in the untreated animals. Survival time of rabbits that received PDT was significantly prolonged compared with that of untreated animals (p = 0.03).

CONCLUSIONS:

PDT was effective for airway stenosis in rabbit models. This suggests that PDT has the potential as a new therapeutic method for airway stenosis originating from granulation tissue.

• Authors: Yoshinori Nakagishi, Yuji Morimoto, Masanori Fujita, Noriko Morimoto, Yuichi Ozeki, Tadaaki Maehara, Makoto Kikuchi
• Journal: Chest (Chest) Vol. 133 Issue 1 Pg. 123-30 (Jan 2008) ISSN: 0012-3692 [Print] United States
• PMID: 17908702 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Disease Models, Animal
• Male
• Photochemotherapy
• Rabbits
• Tracheal Stenosis (drug therapy)