Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women.

Abstract

OBJECTIVE:

To determine whether serum levels of 2 Wnt signaling antagonists, Frizzled-related protein (FRP) and Dkk-1, are associated with the development and progression of radiographic hip osteoarthritis (RHOA).

METHODS:

Pelvic radiographs were obtained a mean of 8.3 years apart in 5,928 Caucasian women >or=65 years of age who were enrolled in the Study of Osteoporotic Fractures. Random sampling of this cohort was performed, with approximately 180 subjects per group assigned to 2 nested case-control studies on RHOA incidence and progression. Baseline serum levels of FRP and Dkk-1 were measured by capture enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression analyses with adjustment for potential covariates.

RESULTS:

There were no differences in serum levels of FRP and Dkk-1 between case subjects with incidence or progression of RHOA and their respective control subjects. There was a trend for higher baseline serum levels of FRP to be associated with a reduced risk of incident RHOA (age-adjusted OR 0.59 [95% CI 0.32-1.09], P = 0.09 for women in the highest quartile versus women in the lowest quartile). There was no association of serum levels of FRP with progression of RHOA. Serum levels of Dkk-1 did not correlate with incident RHOA. However, higher serum levels of Dkk-1 were associated with diminished risk of RHOA progression (age-adjusted OR 0.43 [95% CI 0.23-0.79], P = 0.007 for women in the highest quartile compared with women in the lowest quartile).

CONCLUSION:

Elevated circulating levels of Dkk-1 appeared to be associated with reduced progression of RHOA in elderly women, whereas the highest quartile of serum FRP levels tended to be associated with a modest reduction in risk of incident RHOA.

• Authors: Nancy E Lane, Michael C Nevitt, Li-Yung Lui, Patricia de Leon, Maripat Corr, Study of Osteoporotic Fractures Research Group
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 56 Issue 10 Pg. 3319-25 (Oct 2007) ISSN: 0004-3591 [Print] United States
• PMID: 17907185 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• DKK1 protein, human
• Intercellular Signaling Peptides and Proteins
• Intracellular Signaling Peptides and Proteins
• Proteins
• WD repeat containing planar cell polarity effector
• Wnt Proteins

Topics

• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Case-Control Studies
• Disease Progression
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Intercellular Signaling Peptides and Proteins (blood)
• Intracellular Signaling Peptides and Proteins
• Osteoarthritis, Hip (blood, diagnostic imaging)
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Proteins (analysis)
• Radiography
• Signal Transduction
• White People
• Wnt Proteins (antagonists & inhibitors)