Abstract | PURPOSE: METHODS: In a randomized clinical trial, 38 female patients with rheumatoid arthritis or systemic lupus erithematosus associated with keratoconjunctivitis sicca and Sjögren's syndrome were consecutively selected from patients of the Department of Rheumatology of the Amazonas University Hospital. Keratoconjunctivitis sicca diagnosis was based on a dry-eye symptom survey score (Ocular Surface Disease Index - OSDI), Schirmer-I test, fluorescein break-up time, 1% Rose Bengal staining of ocular surface measured by the van Bijsterveld scale. All patients had ocular surface inflammation evaluated and quantified by conjunctival impression cytology, before and after the study. The subjects were divided into three groups with 13 (Group I), 12 (Group II) and 13 (Group III) patients. Group I received flaxseed oil capsules with a final 1 g/day dosis, Group II flaxseed oil capsules with a final 2 g/day dosis and Group III - controls - placebo, for 180 days. RESULTS: Comparing the results at the beginning and at the end of the treatment, statistically significant changes (p<0.05) in symptoms (OSDI), ocular surface inflammation quantified by conjunctival impression cytology, Schirmer-I test and fluorescein break-up time occurred in Groups I e II when compared to controls. CONCLUSIONS:
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Authors | Manuel Neuzimar Pinheiro Jr, Procópio Miguel dos Santos, Regina Cândido Ribeiro dos Santos, Jeison de Nadai Barros, Luiz Fernando Passos, José Cardoso Neto |
Journal | Arquivos brasileiros de oftalmologia
(Arq Bras Oftalmol)
2007 Jul-Aug
Vol. 70
Issue 4
Pg. 649-55
ISSN: 0004-2749 [Print] Brazil |
Vernacular Title | Uso oral do óleo de linhaça (Linum usitatissimum) no tratamento do olhoseco de pacientesportadores da síndrome de Sjögren. |
PMID | 17906762
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Placebos
- Rose Bengal
- Linseed Oil
- Fluorescein
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Topics |
- Administration, Oral
- Adult
- Arthritis, Rheumatoid
(complications, drug therapy)
- Diagnostic Techniques, Ophthalmological
- Epidemiologic Methods
- Female
- Fluorescein
- Humans
- Keratoconjunctivitis Sicca
(diagnosis, drug therapy)
- Linseed Oil
(administration & dosage, therapeutic use)
- Lupus Erythematosus, Systemic
(complications, drug therapy)
- Middle Aged
- Placebos
- Rose Bengal
- Sjogren's Syndrome
(complications)
- Tears
(physiology)
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