Abstract |
Some early studies have called attention to the potential contribution of sodium (both dietary and serum levels) in airway-related disease, although the picture was not entirely clear. Two recent developments may now allow a more careful consideration of this: first, the greatly improved understanding of the role of salt in hypertension (particularly the identification of subgroups of salt-sensitive individuals within the general population), and second, the recent discovery of the role of the Na(+)/Ca(2+) exchanger in smooth muscle function. Here, we first review those two developments and then apply them to airway smooth muscle and asthma.
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Authors | Simon A Hirota, Luke J Janssen |
Journal | American journal of physiology. Lung cellular and molecular physiology
(Am J Physiol Lung Cell Mol Physiol)
Vol. 293
Issue 6
Pg. L1369-73
(Dec 2007)
ISSN: 1040-0605 [Print] United States |
PMID | 17905852
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Sodium Chloride, Dietary
- Sodium
- Sodium-Potassium-Exchanging ATPase
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Topics |
- Animals
- Asthma
(metabolism)
- Homeostasis
- Humans
- Hypertension
(physiopathology)
- Muscle Contraction
- Muscle, Smooth
(enzymology)
- Rats
- Sodium
(metabolism)
- Sodium Chloride, Dietary
(metabolism)
- Sodium-Potassium-Exchanging ATPase
(metabolism)
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