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Sodium and asthma: something borrowed, something new?

Abstract
Some early studies have called attention to the potential contribution of sodium (both dietary and serum levels) in airway-related disease, although the picture was not entirely clear. Two recent developments may now allow a more careful consideration of this: first, the greatly improved understanding of the role of salt in hypertension (particularly the identification of subgroups of salt-sensitive individuals within the general population), and second, the recent discovery of the role of the Na(+)/Ca(2+) exchanger in smooth muscle function. Here, we first review those two developments and then apply them to airway smooth muscle and asthma.
AuthorsSimon A Hirota, Luke J Janssen
JournalAmerican journal of physiology. Lung cellular and molecular physiology (Am J Physiol Lung Cell Mol Physiol) Vol. 293 Issue 6 Pg. L1369-73 (Dec 2007) ISSN: 1040-0605 [Print] United States
PMID17905852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Sodium Chloride, Dietary
  • Sodium
  • Sodium-Potassium-Exchanging ATPase
Topics
  • Animals
  • Asthma (metabolism)
  • Homeostasis
  • Humans
  • Hypertension (physiopathology)
  • Muscle Contraction
  • Muscle, Smooth (enzymology)
  • Rats
  • Sodium (metabolism)
  • Sodium Chloride, Dietary (metabolism)
  • Sodium-Potassium-Exchanging ATPase (metabolism)

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