Abstract | OBJECTIVES: METHODS: Pregnant mice were fed a soy-free diet and orally gavaged from gestational days 13 to 17 with 0.17 mg/kg/day of genistein, 10 mg/kg/day of vinclozolin, or genistein and vinclozolin together at the same doses, all in 100 microL of corn oil. The controls received the corn oil vehicle. The male fetuses were examined at gestational day 19 for hypospadias, both macroscopically and histologically. RESULTS: CONCLUSIONS: These findings support the idea that exposure to these compounds during gestation could contribute to the development of hypospadias.
|
Authors | Marcelo L B Vilela, Emily Willingham, Jill Buckley, Ben Chun Liu, Koray Agras, Yoshiyuki Shiroyanagi, Laurence S Baskin |
Journal | Urology
(Urology)
Vol. 70
Issue 3
Pg. 618-21
(Sep 2007)
ISSN: 1527-9995 [Electronic] United States |
PMID | 17905137
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Endocrine Disruptors
- Fungicides, Industrial
- Oxazoles
- Pesticide Residues
- Phytoestrogens
- Genistein
- vinclozolin
|
Topics |
- Abnormalities, Drug-Induced
(embryology, etiology)
- Animals
- Diet, Vegetarian
(adverse effects)
- Drug Interactions
- Endocrine Disruptors
(administration & dosage, toxicity)
- Female
- Fetus
(drug effects)
- Food Contamination
- Fungicides, Industrial
(administration & dosage, toxicity)
- Genistein
(administration & dosage, toxicity)
- Gestational Age
- Hypospadias
(chemically induced, embryology)
- Male
- Mice
- Models, Animal
- Oxazoles
(administration & dosage, toxicity)
- Pesticide Residues
(toxicity)
- Phytoestrogens
(administration & dosage, toxicity)
- Pregnancy
|