| Abstract | OBJECTIVES: A study was undertaken to evaluate the diagnostic efficiency of Tc-Tetrofosmin scan and color Doppler in the characterization of benign and malignant solitary thyroid nodules. METHODS: Fifty-two patients found to have a cold solitary thyroid nodule on Tc-pertechnetate scintigraphy were included in this study. All patients underwent a single-injection dual-phase (30 min and 120 min) Tc-Tetrofosmin scan. The intranodular vascularity was measured using color Doppler sonography. Fine-needle aspiration cytology was performed on all the patients. In the following days and weeks all patients underwent surgery. RESULTS: Thirteen out of 15 patients with thyroid cancer showed delayed retention of radiotracer (on 120 min images as compared to the initial 30 min image). Thirty-six out of 37 patients harboring benign solitary nodules showed significant washout of tracer on delayed images. Sensitivity, specificity, positive predictive value and negative predictive value of delayed Tc-Tetrofosmin scintigraphy were found to be 86.6, 97.2, 92.8 and 94.7%, respectively. The Doppler study was able to demonstrate increased vascularity in the center of 8 of the 15 malignant nodules. Thirty-two patients harboring a benign solitary nodule showed normal or increased peripheral vascularity on Doppler study. Sensitivity, specificity, positive predictive value and negative predictive value of color Doppler were found to be 53.5, 86.4, 61.5 and 82%, respectively. CONCLUSION: Delayed Tc-Tetrofosmin scintigraphy is a highly sensitive and specific method for characterizing solitary thyroid nodules, while color Doppler has a low sensitivity but relatively high specificity in differentiating benign from malignant thyroid lesions. |
| Authors | Rajnish Sharma, Kanti Lal Chakravarty, Madhvi Tripathi, Aruna Kaushik, Pooja Bharti, Maheswar Sahoo, Mahender Kumar Chopra, Harish Rawat, Anil Misra, Anupam Mondal, Ravi Kashyap
(Affiliation: Department of Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences (INMAS), Delhi, India. drrsms at rediffmail.com)
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| Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 28
Issue 11
Pg. 847-51
(Nov 2007)
ISSN: 0143-3636 England |
| PMID | 17901767
(Publication Type: Journal Article)
|
| Chemical References |
- Organophosphorus Compounds
- Organotechnetium Compounds
- Radiopharmaceuticals
- technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
|
| Topics |
- Adolescent
- Adult
- Aged
- Biopsy, Fine-Needle
- Child
- Diagnosis, Differential
- Female
- Humans
- Male
- Middle Aged
- Neovascularization, Pathologic
(radionuclide imaging, ultrasonography)
- Organophosphorus Compounds
(diagnostic use)
- Organotechnetium Compounds
(diagnostic use)
- Radiopharmaceuticals
(diagnostic use)
- Thyroid Neoplasms
(pathology, radionuclide imaging, ultrasonography)
- Thyroid Nodule
(pathology, radionuclide imaging, ultrasonography)
- Ultrasonography, Doppler, Color
|
