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[Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer].

Abstract
In a multicentre study, 146 peptic ulcer patients who had recently healed with H2 antagonists (38 gastric, 108 duodenal ulcers) received randomly for a year one of the following mucosal protecting antiulcer drugs: aceglutamide aluminium salt (AAL), zinc acexamate (ZAC) and magaldrate (MAG). Forty six patients received AAL (700 mg bid), 50 patients received ZAC (300 mg at single nocturnal dose) and 50 patients received MAG (800 mg bid). An endoscopic examination was performed at the beginning of the study and 12 months later. Clinical examinations where performed on months 3, 6 and 9, advancing the endoscopical control in case of ulcer symptoms. ZAC showed to be superior to MAG (p less than 0.05, chi-square test) in preventing relapses, with a favourable tendence in front of AAL, but without reaching statistical significance. Its important to mention the high number of withdrawals and the good tolerance of the treatments.
AuthorsM J Varas Lorenzo, A López Martínez, J Gordillo Bernal, J Mundet Surroca
JournalRevista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva (Rev Esp Enferm Dig) Vol. 80 Issue 2 Pg. 91-4 (Aug 1991) ISSN: 1130-0108 [Print] Spain
Vernacular TitleEstudio comparativo de tres fármacos (aceglutamida alumínica, acexamato de zinc y magaldrato) en el tratamiento de mantenimiento a largo plazo (un año) de la úlcera péptica.
PMID1790087 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Aminocaproates
  • Antacids
  • Anti-Ulcer Agents
  • Organometallic Compounds
  • Glutamine
  • Aluminum Hydroxide
  • magaldrate
  • 6-acetylaminocaproic acid
  • Magnesium Hydroxide
  • aceglutamide aluminum
  • Aminocaproic Acid
Topics
  • Adult
  • Aluminum Hydroxide (therapeutic use)
  • Aminocaproates
  • Aminocaproic Acid (therapeutic use)
  • Antacids (therapeutic use)
  • Anti-Ulcer Agents (therapeutic use)
  • Female
  • Glutamine (analogs & derivatives, therapeutic use)
  • Humans
  • Magnesium Hydroxide (therapeutic use)
  • Male
  • Middle Aged
  • Organometallic Compounds (therapeutic use)
  • Peptic Ulcer (drug therapy)
  • Recurrence
  • Time Factors

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