Effects of melatonin and rilmazafone on nocturia in the elderly.

Abstract

We compared the effects of melatonin, an antioxidant and sleep inducer in humans, and rilmazafone hydrochloride, a hypnotic, in elderly patients with nocturia. Patients received either melatonin (2 mg/day; n = 20) or rilmazafone (2 mg/day; n = 22) for 4 weeks. There were no significant differences in the mean age, the quality of life (QoL) score and the serum melatonin levels between the two groups at baseline. After 4 weeks' treatment, the number of nocturnal urinations was significantly decreased and the QoL score was significantly improved in both groups. There was no significant difference between the patient-reported effectiveness ratings between the two groups. The serum melatonin level was significantly increased in the melatonin-treated group, but it remained unchanged in the rilmazafone-treated group. Melatonin and rilmazafone were equally effective for nocturia in the elderly. We recommend that the problems of sleep disturbance should be considered when choosing a therapy for nocturia.

• Authors: K Sugaya, S Nishijima, M Miyazato, K Kadekawa, Y Ogawa
• Journal: The Journal of international medical research (J Int Med Res) 2007 Sep-Oct Vol. 35 Issue 5 Pg. 685-91 ISSN: 0300-0605 [Print] England
• PMID: 17900408 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Hypnotics and Sedatives
• Triazoles
• rilmazafone
• Melatonin

Topics

• Aged
• Female
• Humans
• Hypnotics and Sedatives (therapeutic use)
• Male
• Melatonin (blood, therapeutic use)
• Nocturia (drug therapy, physiopathology)
• Quality of Life
• Triazoles (therapeutic use)