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A role for T cell-derived interleukin 22 in psoriatic skin inflammation.

Abstract
Interleukin (IL)-22 is a T cell-derived cytokine that has been reported recently to induce cutaneous inflammation in an experimental murine model of psoriasis, and to induce in vitro an inflammatory-like phenotype. In the present study, we assessed the presence of IL-22 and the IL-22 receptor 1 (IL-22R1) in skin lesions, skin-derived T cells, as well as IL-22 levels in sera from patients with psoriasis. IL-22R1 and IL-10R2 transcripts are expressed at a similar level in psoriatic and healthy skin. In contrast, IL-22 mRNA expression was up-regulated in psoriatic skin lesions compared to normal skin, whereas IL-22 mRNA levels in peripheral blood mononuclear cells from psoriatic patients and normal subjects were similar. Circulating IL-22 levels were significantly higher in psoriatic patients than in normal subjects. T cells isolated from psoriatic skin produced higher levels of IL-22 in comparison to peripheral T cells isolated from the same patients. IL-10 was expressed at similar levels in skin biopsies and peripheral blood mononuclear cells of psoriatic patients and normal subjects. Finally, we show here that supernatants of lesional psoriatic skin-infiltrating T cells induce an inflammatory response by normal human epidermal keratinocytes, resembling that observed in psoriatic lesions. Taken together, the results reported in this study indicate that IL-22 is a cytokine produced by skin-infiltrating lymphocytes that is potentially involved in initiation and/or maintenance of the pathogenesis of psoriasis.
AuthorsK Boniface, E Guignouard, N Pedretti, M Garcia, A Delwail, F-X Bernard, F Nau, G Guillet, G Dagregorio, H Yssel, J-C Lecron, F Morel
JournalClinical and experimental immunology (Clin Exp Immunol) Vol. 150 Issue 3 Pg. 407-15 (Dec 2007) ISSN: 1365-2249 [Electronic] England
PMID17900301 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Inflammation Mediators
  • Interleukins
  • RNA, Messenger
  • Receptors, Interleukin
  • interleukin-22
  • interleukin-22 receptor
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Cells, Cultured
  • Female
  • Gene Expression Profiling (methods)
  • Humans
  • Inflammation Mediators (metabolism)
  • Interleukins (biosynthesis, genetics, immunology)
  • Keratinocytes (immunology)
  • Male
  • Middle Aged
  • Psoriasis (immunology)
  • RNA, Messenger (genetics)
  • Receptors, Interleukin (metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction (methods)
  • Skin (immunology)
  • T-Lymphocytes (immunology)
  • Up-Regulation

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