Combined effect of Neridronate and specific antibiotic therapy in a case of tuberculous spondylodiscitis.

Abstract

Because of the increased incidence of tuberculosis (TB) in recent years, infective spondylitis is still a major problem in the world. In skeletal TB the spine is the most often involved and lumbosacral spine involvement is rare. Nowadays early diagnosis and new medical treatment can reduce the incidence of the serious skeletal sequelae and the number of surgery procedures in spinal TB. We present a case of TB spondylodiscitis characterized by a rapid and progressive clinical and radiological improvement after treatment with Neridronate and chemotherapic drugs. Our data suggest that in the treatment of the TB spondylodiscitis the combined use of these drugs is a good alternative to stimulate bone reparative process to the chemotherapy alone. To our knowledge this is first case of a patient with TB discitis treated with Neridronate. Further studies are necessary to confirm the effectiveness of Neridronate treatment added to antiTB drugs in spondylodiscitis.

• Authors: L Quarta, A Corrado, N Melillo, A Trotta, G Scotto, F d'Onofrio, N Santoro, F P Cantatore
• Journal: Rheumatology international (Rheumatol Int) Vol. 28 Issue 5 Pg. 495-8 (Mar 2008) ISSN: 0172-8172 [Print] Germany
• PMID: 17899089 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antitubercular Agents
• Bone Density Conservation Agents
• Diphosphonates
• 6-amino-1-hydroxyhexane-1,1-diphosphonate

Topics

• Anti-Bacterial Agents (therapeutic use)
• Antitubercular Agents (therapeutic use)
• Bone Density Conservation Agents (therapeutic use)
• Diphosphonates (therapeutic use)
• Discitis (drug therapy)
• Drug Therapy, Combination
• Female
• Humans
• Lumbar Vertebrae (microbiology)
• Middle Aged
• Tuberculosis, Spinal (drug therapy)