Abstract | PURPOSE: Inhibition of carbonic anhydrase in the eye is an important treatment modality for reducing the intraocular pressure in glaucoma. However, evidence suggests that carbonic anhydrase inhibition also exerts a relaxing effect on the vessels in the optic nerve, and it has been suggested that this vasorelaxing effect is a result of an interplay between the perivascular tissue and constituents in the retinal vascular wall. However, the exact nature of this interplay is unknown. METHODS: RESULTS: CONCLUSIONS: A further elucidation of the mechanisms of action of carbonic anhydrase-induced dilation of retinal arterioles may contribute to a better understanding of the regulation of retinal blood flow. The perivascular retinal tissue may play a significant role in diameter control of retinal arterioles.
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Authors | Anne Katrine Kehler, Kim Holmgaard, Anders Hessellund, Christian Aalkjaer, Toke Bek |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 48
Issue 10
Pg. 4688-93
(Oct 2007)
ISSN: 0146-0404 [Print] United States |
PMID | 17898293
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbonic Anhydrase Inhibitors
- Sulfonamides
- Thiophenes
- Vasoconstrictor Agents
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
- dorzolamide
- Acetazolamide
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Topics |
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
(pharmacology)
- Acetazolamide
(pharmacology)
- Animals
- Arterioles
(physiology)
- Carbonic Anhydrase Inhibitors
(pharmacology)
- Muscle, Smooth, Vascular
(drug effects)
- Myography
- Retinal Artery
(physiology)
- Sulfonamides
(pharmacology)
- Swine
- Thiophenes
(pharmacology)
- Vasoconstrictor Agents
(pharmacology)
- Vasodilation
(physiology)
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