A) OBJECTIVES: Investigations of the four synthetic
coumarin-related compounds: N' - allylthiouridine-3-carbamoil
coumarin (GSH-16), N'- morpholylthiouridine-3-carbamoil
coumarin (GSH-17), N'-O-fluor-benzyl-N'-3-carbamoil piperaside
coumarin (GSH-10) and 6-nitroallylamide-3-carboxy
coumarin (GSH-84), were done for study of their role in the processes of hemocoagulation. B) DESIGN AND METHODS: Investigations were carried out on 120 white rats (180-200g), which were injected intravenously by 0.5 ml and 1.0 ml of 1 %
solution of GSH-17 and decapitated after 10 and 30 min after the injection by use of light
chloroform narcosis. Separation of the liver was done by simultaneous washing with cold physiological
solution. C) RESULTS: It was shown that the hemostabilization action of GSH-17 is highly dose- and time - dependent, with by the pronounced decrease of rat liver thromboplastic activity after 10 and especially 30 min following
intravenous injection. D) CONCLUSION: One of the possible mechanisms for haemostatic effect of the studied preparations, particularly GSH-17, probably can be accepted their effect on metabolism of
arachidonic acid by
lipoxygenase and cycloxygenase mechanisms [9, 10]. The results of this investigations have not only the academic interest, but they have also a significant importance for definite branches of practical medicine as a very effective blood stabilizing factors.