Usefulness of combining sequentially acquired gadobenate dimeglumine-enhanced magnetic resonance imaging and resovist-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: comparison with computed tomography hepatic arteriography and computed tomography arterioportography using 16-slice multidetector computed tomography.

Abstract

OBJECTIVE:

To investigate the diagnostic efficacy of sequentially acquired gadobenete dimeglumine-enhanced 3-dimensional dynamic magnetic resonance imaging (MRI) and Resovist-enhanced MRI for detecting hepatocellular carcinoma (HCC) by comparing with combined computed tomography (CT) hepatic arteriography (CTHA) and CT arterioportography (CTAP) using 16-slice multidetector CT.

MATERIALS:

Twenty-nine patients with 50 HCCs underwent sequentially acquired double-contrast MRI--gadobenate dimeglumine-enhanced dynamic MRI and Resovist-enhanced MRI--and combined CTHA and CTAP using 16-slice multidetector CT. Dynamic MRI was obtained using volumetric interpolated technique and sensitivity encoding on a 1.5-T unit. Resovist-enhanced MRI was composed of T2-weighted turbo spin-echo and T2*-weighted gradient echo sequences. Sensitivity, positive predictive value, and diagnostic accuracy for double-contrast MRI, gadolinium-enhanced MRI, and combined CTHA and CTAP were calculated by 2 observers using an alternative-free response receiver operating characteristic analysis.

RESULTS:

For all observers, the Az values of double-contrast MRI (mean, 0.96) and combined CTHA and CTAP (mean, 0.93) were similar, which tended to be better than that of gadolinium-enhanced MRI (mean, 0.91). The sensitivity of double-contrast MRI (mean, 93%) and combined CTHA and CTAP (mean, 92%) was equivalent for all observers, which was better than that of gadolinium-enhanced MRI (mean, 85%; P < 0.05). The positive predictive value of double-contrast MRI was better than that of combined CTHA and CTAP (P < 0.05).

CONCLUSION:

The sequentially acquired double-contrast MRI and combined CTHA and CTAP showed a similar diagnostic accuracy and sensitivity for detecting HCC.

• Authors: Young Kon Kim, Hyo Sung Kwak, Young Min Han, Chong Soo Kim
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) 2007 Sep-Oct Vol. 31 Issue 5 Pg. 702-11 ISSN: 0363-8715 [Print] United States
• PMID: 17895780 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• Dextrans
• Magnetite Nanoparticles
• Organometallic Compounds
• Oxides
• gadobenic acid
• Meglumine
• Iron
• ferumoxides
• Ferrosoferric Oxide

Topics

• Angiography (methods)
• Carcinoma, Hepatocellular (diagnosis, diagnostic imaging, therapy)
• Combined Modality Therapy
• Contrast Media
• Dextrans
• Female
• Ferrosoferric Oxide
• Humans
• Image Processing, Computer-Assisted
• Imaging, Three-Dimensional
• Iron
• Liver Neoplasms (diagnosis, diagnostic imaging, therapy)
• Magnetic Resonance Imaging (methods)
• Magnetite Nanoparticles
• Male
• Meglumine (analogs & derivatives)
• Middle Aged
• Organometallic Compounds
• Oxides
• ROC Curve
• Retrospective Studies
• Sensitivity and Specificity
• Tomography, X-Ray Computed (methods)
• Treatment Outcome