Statins increase risk of hemorrhagic stroke by inhibition of the PAR-1 receptor.

• Authors: Victor L Serebruany, Alex I Malinin, Charles H Hennekens
• Journal: Cerebrovascular diseases (Basel, Switzerland) (Cerebrovasc Dis) Vol. 24 Issue 5 Pg. 477-9 ( 2007) ISSN: 1015-9770 [Print] Switzerland
• PMID: 17895623 (Publication Type: Journal Article)

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Receptor, PAR-1

Topics

• Cerebral Hemorrhage (chemically induced, complications, metabolism)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)
• Receptor, PAR-1 (antagonists & inhibitors, metabolism)
• Risk Assessment
• Risk Factors
• Stroke (etiology, metabolism)