Chemoprophylactic effects of milbemycin oxime against larvae of Dirofilaria immitis during prepatent development.

Three studies were conducted to determine the efficacy of milbemycin oxime in the prevention of Dirofilaria immitis infection in dogs. Dogs were given single or multiple experimental inoculations with infective third-stage D immitis larvae and were treated with milbemycin oxime at a target dosage of 0.5 mg/kg of body weight either once or at monthly intervals at various times after inoculation. The compound was effective in preventing infection when 1 dose was administered 30 or 45 days after inoculation. Significant, but incomplete, protection was achieved when single treatments were administered 60 or 90 days after inoculation. Multiple monthly treatments beginning 60 days after inoculation appeared to provide additive effects that resulted in restoration of complete efficacy.
AuthorsR B Grieve, G R Frank, V A Stewart, J C Parsons, D L Belasco, D I Hepler
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 52 Issue 12 Pg. 2040-2 (Dec 1991) ISSN: 0002-9645 [Print] UNITED STATES
PMID1789519 (Publication Type: Journal Article)
Chemical References
  • Anthelmintics
  • Anti-Bacterial Agents
  • Macrolides
  • milbemycin
  • Animals
  • Anthelmintics (pharmacology, therapeutic use)
  • Anti-Bacterial Agents (pharmacology, therapeutic use)
  • Dirofilaria immitis (drug effects)
  • Dirofilariasis (prevention & control, veterinary)
  • Dog Diseases (prevention & control)
  • Dogs
  • Female
  • Larva (drug effects)
  • Macrolides
  • Male

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