Abstract | BACKGROUND: In an attempt to further improve patient preparation experience with reduced volume gut lavage solutions using 2-L sulphate-free electrolyte lavage solution plus 20-mg bisacodyl (HalfLytely with Bisacodyl Tablets Bowel Prep Kit, Braintree Laboratories, Inc., Braintree, MA, USA), a low bisacodyl dose preparation was developed using 10 mg bisacodyl. AIM: To compare preparation methods using the 10- or 20-mg bisacodyl with 2-L sulphate-free electrolyte lavage method. METHODS:
At 10 US centres, 455 patients undergoing colonoscopy for routine clinical indications were equally randomized to receive 10- or 20-mg bisacodyl with 2-L sulphate-free electrolyte lavage method. Colonoscopists rated the efficacy of colon cleansing, blinded to the preparation assignment. RESULTS: Physician assessment of colon cleansing showed no difference between those randomized to receive the 10- or 20-mg bisacodyl preparations (P = 0.52). The 10-mg preparation had lower symptom scores for cramping (P < 0.001) and overall discomfort (P = 0.001). Other reported adverse experiences were few, mild and not different between groups. CONCLUSION: Two-litre sulphate-free electrolyte lavage method solution with 10-mg bisacodyl is as effective as the 20-mg bisacodyl preparation for cleansing the colon prior to colonoscopy. The 10-mg bisacodyl regimen has an improved safety profile, with significantly reduced cramping, nausea and overall discomfort.
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Authors | J A DiPalma, J McGowan, M Vb Cleveland |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 26
Issue 8
Pg. 1113-9
(Oct 15 2007)
ISSN: 0269-2813 [Print] England |
PMID | 17894653
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cathartics
- Bisacodyl
- Polyethylene Glycols
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bisacodyl
(administration & dosage, adverse effects)
- Cathartics
(administration & dosage, adverse effects)
- Colonoscopy
(methods)
- Dose-Response Relationship, Drug
- Female
- Gastric Lavage
(methods)
- Humans
- Male
- Middle Aged
- Patient Compliance
- Polyethylene Glycols
(administration & dosage, adverse effects)
- Preoperative Care
(methods)
- Treatment Outcome
- United States
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