| Abstract | Ductal carcinoma in situ (DCIS) is a preinvasive breast lesion accounting for approximately 30% of all newly detected breast cancers in the US. DCIS has been separated into two groups by architecture (comedo versus noncomedo) and nuclear grade. The expression of biological markers in DCIS, however, would reflect the true biologic potential of the lesion. Patients with estrogen receptor (ER)-negative, human epidermal growth factor-2 (HER-2)-positive DCIS pose a treatment challenge. They are not candidates for tamoxifen; trastuzumab has an undetermined role in DCIS. In this report, we present a case of a 45-year-old woman diagnosed with invasive breast cancer and ER-negative/HER-2-positive DCIS who developed recurrence and progression of DCIS as manifested by a new palpable mass while receiving trastuzumab as part of adjuvant treatment for invasive breast cancer. The potential clinical implications are discussed. |
| Authors | Zeina Nahleh, Azadeh Namakydoust, Rania Bakkar, John Bishop
(Affiliation: Karmanos Cancer Institute/Wayne State University, Detroit, Michigan ,College of Medicine, Department of Pathology, University of Cincinnati, Cincinnati, Ohio, USA.)
|
| Journal | Anti-cancer drugs
(Anticancer Drugs)
Vol. 18
Issue 10
Pg. 1231-5
(Nov 2007)
ISSN: 0959-4973 England |
| PMID | 17893526
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Antibodies, Monoclonal
- Antineoplastic Agents
- Receptors, Estrogen
- trastuzumab
- Receptor, erbB-2
|
| Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Antineoplastic Agents
(therapeutic use)
- Breast Neoplasms
(drug therapy, metabolism)
- Carcinoma, Intraductal, Noninfiltrating
(drug therapy, metabolism)
- Chemotherapy, Adjuvant
- Female
- Humans
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
- Receptor, erbB-2
(metabolism)
- Receptors, Estrogen
(metabolism)
- Treatment Failure
|
