Abstract | BACKGROUND/AIMS: METHODS: dTGR were gavaged daily with either S18886 (30 mg/kg/day, n = 12), or placebo (dTGR- Plac, tap water, n = 14) for 3 weeks. Matched Sprague-Dawley rats (n = 10) served as controls. RESULTS: The dTGR- Plac had higher systolic blood pressure (1.7-fold) than controls, and developed profound renal damage with significantly higher proteinuria (6.9-fold), polyuria (2.3-fold), index of glomerulosclerosis (+58%), and tubulointerstitial (+47%) and vascular damage scores (+19%). Creatinine concentration and the mesangiolysis index remained unchanged. In dTGR, S18886 slightly lowered the blood pressure (162 +/- 15 vs. 149 +/- 13 mm Hg, not significant) and improved proteinuria (558 +/- 218 vs. 136 +/- 71 mg/micromol creatinine, p < 0.01), polyuria and renal morphology (glomerulosclerosis index: 0.79 +/- 0.05 vs. 0.66 +/- 0.13, p < 0.01; tubulointerstitial damage index: 1.82 +/- 0.22 vs. 1.49 +/- 0.27, p < 0.05; mesangiolysis index: 1.31 +/- 0.18 vs. 0.36 +/- 0.09, p < 0.01). Vascular damage score and plasma creatinine were not influenced. S18886 did not alter measured markers of oxidative stress. CONCLUSION:
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Authors | Katarína Sebeková, Anika Ramuscak, Peter Boor, August Heidland, Kerstin Amann |
Journal | American journal of nephrology
(Am J Nephrol)
Vol. 28
Issue 1
Pg. 47-53
( 2008)
ISSN: 1421-9670 [Electronic] Switzerland |
PMID | 17890857
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2007 S. Karger AG, Basel. |
Chemical References |
- Naphthalenes
- Propionates
- Receptors, Thromboxane
- Vasoconstrictor Agents
- Angiotensinogen
- Angiotensin II
- terutroban
- Renin
|
Topics |
- Angiotensin II
- Angiotensinogen
(genetics)
- Animals
- Animals, Genetically Modified
- Humans
- Hypertension, Renal
(chemically induced, drug therapy, pathology)
- Kidney Glomerulus
(pathology)
- Male
- Naphthalenes
(pharmacology)
- Propionates
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Thromboxane
(antagonists & inhibitors)
- Renin
(genetics)
- Vasoconstrictor Agents
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