Abstract | PURPOSE: SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex ( C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS:
Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.
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Authors | Matthias G Wirtitsch, Rupert Menapace, Michael Georgopoulos, Georg Rainer, Wolf Buehl, Harald Heinzl |
Journal | Journal of cataract and refractive surgery
(J Cataract Refract Surg)
Vol. 33
Issue 10
Pg. 1754-9
(Oct 2007)
ISSN: 0886-3350 [Print] United States |
PMID | 17889772
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antihypertensive Agents
- Sulfonamides
- Thiophenes
- Timolol
- dorzolamide
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Topics |
- Aged
- Aged, 80 and over
- Antihypertensive Agents
(administration & dosage, adverse effects)
- Capsulorhexis
(methods)
- Cataract
(complications)
- Combined Modality Therapy
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Intraocular Pressure
- Lens Implantation, Intraocular
- Lenses, Intraocular
- Male
- Middle Aged
- Ocular Hypertension
(prevention & control)
- Postoperative Complications
- Prospective Studies
- Prosthesis Design
- Sulfonamides
(administration & dosage, adverse effects)
- Thiophenes
(administration & dosage, adverse effects)
- Timolol
(administration & dosage, adverse effects)
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