Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.

Abstract

Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer.

• Authors: Yongge Qiu, Jinbo Gao, Fei Guo, Yuqin Qiao, Ding Li
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 17 Issue 22 Pg. 6164-8 (Nov 15 2007) ISSN: 0960-894X [Print] England
• PMID: 17888661 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol
• Carboxy-Lyases
• pyrophosphomevalonate decarboxylase

Topics

• Animals
• Carboxy-Lyases (antagonists & inhibitors, chemistry, genetics)
• Cholesterol (metabolism)
• Drug Evaluation, Preclinical
• Inhibitory Concentration 50
• Kinetics
• Liver (enzymology)
• Molecular Structure
• Mutagenesis, Site-Directed
• Rats
• Signal Transduction (drug effects)
• Structure-Activity Relationship
• Substrate Specificity (genetics)
• Yeasts (enzymology)