| Abstract | Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a given visual stimulus in a naming task. Therefore, we tested naming in a pilot study of chronic Broca's aphasia patients with anomia after propranolol and after placebo in a double-blinded crossover manner. Naming was better after propranolol than after placebo, suggesting a potential benefit from propranolol in chronic Broca's aphasia with anomia. Larger follow-up studies are necessary to further investigate this effect. |
| Authors | David Q Beversdorf, Umesh K Sharma, Nicole N Phillips, Margaret A Notestine, Andrew P Slivka, Norman M Friedman, Sandra L Schneider, Haikady N Nagaraja, Ashleigh Hillier
(Affiliation: Department of Neurology, The Ohio State University Medical Center, Columbus, OH 43210, USA. david.beversdorf at osumc.edu)
|
| Journal | Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology
(Neurocase)
Vol. 13
Issue 4
Pg. 256-9
(Aug 2007)
ISSN: 1355-4794 England |
| PMID | 17886000
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Adrenergic beta-Antagonists
- Propranolol
|
| Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Aged
- Analysis of Variance
- Anomia
(drug therapy, etiology, physiopathology)
- Aphasia, Broca
(complications, drug therapy, etiology)
- Association Learning
(drug effects)
- Humans
- Language Tests
- Middle Aged
- Names
- Neuropsychological Tests
- Propranolol
(therapeutic use)
- Reaction Time
(drug effects)
- Stroke
(complications)
|
