Abstract | OBJECTIVES: METHODS: Fifty patients with untreated essential hypertension were randomized to receive 5 mg of amlodipine (n = 25) or 10 mg of cilnidipine (n = 25) once daily in the morning for 24 weeks. The patients were evaluated before and after the therapy to assess changes in renal function, flow-mediated vasodilation (a parameter of vascular endothelial function), and brachial-ankle pulse wave velocity (a parameter of arterial stiffness). RESULTS: Before treatment, the above parameters showed no significant differences between groups. After treatment, urinary albumin excretion was decreased significantly in the cilnidipine group compared with the amlodipine group, and the decrease of brachial-ankle pulse wave velocity was significantly larger in the cilnidipine group than in the amlodipine group. CONCLUSIONS:
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Authors | Satoshi Morimoto, Yutaka Yano, Kei Maki, Toshiji Iwasaka |
Journal | Journal of hypertension
(J Hypertens)
Vol. 25
Issue 10
Pg. 2178-83
(Oct 2007)
ISSN: 0263-6352 [Print] England |
PMID | 17885563
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antihypertensive Agents
- Calcium Channel Blockers
- Dihydropyridines
- Amlodipine
- cilnidipine
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Topics |
- Albuminuria
(prevention & control)
- Amlodipine
(adverse effects, therapeutic use)
- Antihypertensive Agents
(adverse effects, therapeutic use)
- Arteries
(drug effects, physiopathology)
- Calcium Channel Blockers
(adverse effects, therapeutic use)
- Dihydropyridines
(therapeutic use)
- Endothelium, Vascular
(drug effects, physiopathology)
- Female
- Humans
- Hypertension
(complications, drug therapy, physiopathology)
- Kidney
(drug effects, physiopathology)
- Male
- Middle Aged
- Safety
- Vasodilation
(drug effects)
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