Human papillomavirus in lesions of anogenital mammary-like glands.

Abstract

Long considered as ectopic breast tissue, anogenital mammary-like glands (MLGs) have recently been suggested to represent distinctive structures located in the anogenital area. We studied 16 neoplasms of anogenital MLG for human papillomavirus (HPV) DNA using INNO-line probe assay (LiPA) HPV Genotyping kit, GP5+/6+, CP(SGB), and FAP 6085-6319 primer sets. The lesions included 3 fibroadenomas, 2 adenosis tumors, 1 invasive ductal carcinoma, 1 tubulolobular carcinoma, 2 hidradenoma papilliferum with prominent cystic change rendering a cystadenoma appearance and oxyphilic metaplasia, and 7 cases of extramammary Paget disease. All 3 fibroadenomas, both adenosis tumors, both hidradenoma papilliferum, and the tubulolobular carcinoma proved negative for HPV DNA. HPV-31 was detected by LiPA in the case of invasive ductal carcinoma. In 2 of the 7 patients with extramammary Paget disease, there was HPV DNA present in the lesional tissue, typed as HPV-6 (LiPA) and a type which was closely related to HPV-21 and HPV-24 (FAP 6085-6319), whereas the remaining 5 cases tested negative. These results coupled with those obtained from literature review suggest that HPV plays no causative role in lesions of anogenital MLG.

• Authors: Dmitry V Kazakov, Jana Nemcova, Iva Mikyskova, Irena E Belousova, Marina Vazmitel, Michal Michal
• Journal: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 26 Issue 4 Pg. 475-80 (Oct 2007) ISSN: 0277-1691 [Print] United States
• PMID: 17885501 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Anus Neoplasms (virology)
• Exocrine Glands (pathology)
• Female
• Genital Neoplasms, Female (virology)
• Humans
• Male
• Middle Aged
• Papillomaviridae (isolation & purification)
• Papillomavirus Infections (epidemiology)
• Polymerase Chain Reaction
• Tumor Virus Infections (epidemiology)