| Abstract | BACKGROUND AND PURPOSE: This study was undertaken to analyze the outcomes and treatment-related complications of the polyglycolic/polylactic acid (PGLA)-coated Matrix platinum coils in the treatment of intracranial aneurysms and compare these results with those derived from the same single-institutional experience with use of uncoated, bare platinum coils. MATERIALS AND METHODS: In this study, we compared 2 groups of patients in a retrospective fashion. The first group consisted of 70 consecutive patients who underwent 82 aneurysm treatments with Matrix coils during the 14-month period of study, from January 2003 to February 2004. We compared this cohort with 70 consecutive patients who underwent a total of 80 aneurysm treatments with bare platinum coils in the 12 months immediately preceding the use of PGLA-coated coils, from January through December 2002. We then recorded the treatment characteristics, angiographic outcomes, and any complications. RESULTS: There were similar baseline demographic characteristics between the 2 study groups except in age, anatomic location, and length of follow-up. The overall recurrence rate of aneurysms was 41% among the Matrix-treated group and 32% among the patients treated with bare platinum. Among the 42 patients treated with 100% Matrix, the rate of recurrence was 31%. Of the recurrences, 21% of the Matrix group, 19% of the 100% Matrix group, and 9% of the bare platinum group required retreatment. The overall rate of complications was 10% in the Matrix-treated group and 7% in the bare platinum group. There was not a statistically significant difference in the rate of recurrence of aneurysms or complications between the 2 groups. CONCLUSIONS: On the basis of our single-center experience, there is insufficient evidence to support the use of Matrix coils over bare platinum coils, given their disadvantages. |
| Authors | D J Rivet, C J Moran, A Mazumdar, T K Pilgram, C P Derdeyn, D T Cross
(Affiliation: Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA. dennis.rivet at med.navy.mil)
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| Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 28
Issue 9
Pg. 1736-42
(Oct 2007)
ISSN: 0195-6108 United States |
| PMID | 17885252
(Publication Type: Comparative Study, Evaluation Studies, Journal Article)
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| Chemical References |
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| Topics |
- Embolization, Therapeutic
(instrumentation, methods)
- Equipment Design
- Equipment Failure Analysis
- Female
- Humans
- Intracranial Aneurysm
(radiography, therapy)
- Male
- Middle Aged
- Platinum
- Recurrence
(prevention & control)
- Retrospective Studies
- Treatment Outcome
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