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Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts.

AbstractAIM:
In order to elucidate the molecular mechanism underlying the cardioprotection afforded by schisandrin B (Sch B), the effect of Sch B treatment on the sensitivity of mitochondria to Ca2+-stimulated permeability transition (PT) was investigated in rat hearts under normal and ischemia-reperfusion (I-R) conditions.
RESULTS:
Myocardial I-R injury caused an increase in the sensitivity of mitochondria to Ca2+-stimulated PT in vitro. The enhanced sensitivity to mitochondrial PT was associated with increases in mitochondrial Ca2+ content as well as the extent of reactive oxidant species production in vitro and cytochrome c release in vivo. The cardioprotection afforded by Sch B pretreatment against I-R-induced injury was paralleled by the decrease in the sensitivity of myocardial mitochondria to Ca2+-stimulated PT, particularly under I-R conditions.
CONCLUSION:
The results suggest that Sch B treatment increases the resistance of myocardial mitochondria to Ca2+-stimulated PT and protects against I-R-induced tissue injury.
AuthorsPo-Yee Chiu, Hoi-Yan Leung, Ada Hl Siu, Michel Kt Poon, Kam-Ming Ko
JournalActa pharmacologica Sinica (Acta Pharmacol Sin) Vol. 28 Issue 10 Pg. 1559-65 (Oct 2007) ISSN: 1671-4083 [Print] United States
PMID17883940 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cardiotonic Agents
  • Cyclooctanes
  • Lignans
  • Mitochondrial Membrane Transport Proteins
  • Mitochondrial Permeability Transition Pore
  • Polycyclic Compounds
  • Reactive Oxygen Species
  • schizandrin B
  • Cytochromes c
  • Calcium
Topics
  • Animals
  • Calcium (metabolism, pharmacology)
  • Cardiotonic Agents (isolation & purification, pharmacology)
  • Cyclooctanes (isolation & purification, pharmacology)
  • Cytochromes c (metabolism)
  • Fruit (chemistry)
  • Lignans (isolation & purification, pharmacology)
  • Mitochondria, Heart (drug effects, metabolism)
  • Mitochondrial Membrane Transport Proteins (metabolism)
  • Mitochondrial Permeability Transition Pore
  • Myocardial Reperfusion Injury (metabolism, prevention & control)
  • Plants, Medicinal (chemistry)
  • Polycyclic Compounds (isolation & purification, pharmacology)
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species (metabolism)
  • Schisandra (chemistry)

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