Abstract | AIM: In order to elucidate the molecular mechanism underlying the cardioprotection afforded by schisandrin B (Sch B), the effect of Sch B treatment on the sensitivity of mitochondria to Ca2+-stimulated permeability transition (PT) was investigated in rat hearts under normal and ischemia-reperfusion (I-R) conditions. RESULTS: Myocardial I-R injury caused an increase in the sensitivity of mitochondria to Ca2+-stimulated PT in vitro. The enhanced sensitivity to mitochondrial PT was associated with increases in mitochondrial Ca2+ content as well as the extent of reactive oxidant species production in vitro and cytochrome c release in vivo. The cardioprotection afforded by Sch B pretreatment against I-R-induced injury was paralleled by the decrease in the sensitivity of myocardial mitochondria to Ca2+-stimulated PT, particularly under I-R conditions. CONCLUSION: The results suggest that Sch B treatment increases the resistance of myocardial mitochondria to Ca2+-stimulated PT and protects against I-R-induced tissue injury.
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Authors | Po-Yee Chiu, Hoi-Yan Leung, Ada Hl Siu, Michel Kt Poon, Kam-Ming Ko |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 28
Issue 10
Pg. 1559-65
(Oct 2007)
ISSN: 1671-4083 [Print] United States |
PMID | 17883940
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cardiotonic Agents
- Cyclooctanes
- Lignans
- Mitochondrial Membrane Transport Proteins
- Mitochondrial Permeability Transition Pore
- Polycyclic Compounds
- Reactive Oxygen Species
- schizandrin B
- Cytochromes c
- Calcium
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Topics |
- Animals
- Calcium
(metabolism, pharmacology)
- Cardiotonic Agents
(isolation & purification, pharmacology)
- Cyclooctanes
(isolation & purification, pharmacology)
- Cytochromes c
(metabolism)
- Fruit
(chemistry)
- Lignans
(isolation & purification, pharmacology)
- Mitochondria, Heart
(drug effects, metabolism)
- Mitochondrial Membrane Transport Proteins
(metabolism)
- Mitochondrial Permeability Transition Pore
- Myocardial Reperfusion Injury
(metabolism, prevention & control)
- Plants, Medicinal
(chemistry)
- Polycyclic Compounds
(isolation & purification, pharmacology)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(metabolism)
- Schisandra
(chemistry)
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