Ring chromosome 12 and severe oligospermia: a case report.

Abstract

OBJECTIVE:

To describe an unusual presentation of ring chromosome 12, which manifested as severe azoospermia, resulting in male infertility.

DESIGN:

Case report.

SETTING:

In vitro fertilization center at a tertiary care hospital.

PATIENT(S):

A 27-year-old man diagnosed with unexplained azoospermia and ring chromosome 12 abnormality during a workup for primary infertility.

INTERVENTION(S):

In vitro fertilization with preimplantation genetic diagnosis.

MAIN OUTCOME MEASURE(S):

To confirm the importance of obtaining karyotypes in individuals with severe oligospermia.

RESULT(S):

Full-term pregnancy after IVF using donor sperm.

CONCLUSION(S):

Severe oligospermia and male infertility should be included in the spectrum of findings found in ring chromosome 12.

• Authors: J Ryan Martin, Anne Wold, Hugh S Taylor
• Journal: Fertility and sterility (Fertil Steril) Vol. 90 Issue 2 Pg. 443.e13-5 (Aug 2008) ISSN: 1556-5653 [Electronic] United States
• PMID: 17880954 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Azoospermia (genetics)
• Chromosomes, Human, Pair 12
• Female
• Fertilization in Vitro
• Humans
• Infertility, Male (genetics)
• Insemination, Artificial, Heterologous
• Learning Disabilities (genetics)
• Male
• Microcephaly (genetics)
• Pregnancy
• Preimplantation Diagnosis
• Ring Chromosomes