Abstract | BACKGROUND: METHODS: Biopsy samples from 28 sclerosing and infiltrating basal cell carcinomas, 13 microcystic adnexal carcinomas and 16 desmoplastic trichoepitheliomas were examined after immunohistochemical staining with Ber-EP4. RESULTS: Ber-EP4 did not label any of the microcystic adnexal carcinomas, whereas all 28 basal cell carcinomas were Ber-EP4 positive. Twenty-seven of the 28 showed moderate or strong staining intensity, with the majority being strong. Only one basal cell carcinoma was weakly positive. Twelve of the 16 desmoplastic trichoepitheliomas were immunoreactive with Ber-EP4 and the staining was more variable than those of basal cell carcinomas. CONCLUSIONS:
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Authors | Dieter Krahl, Klaus Sellheyer |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 34
Issue 10
Pg. 782-7
(Oct 2007)
ISSN: 0303-6987 [Print] United States |
PMID | 17880584
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- human epithelial antigen-125
|
Topics |
- Biomarkers, Tumor
(metabolism)
- Biopsy
- Carcinoma, Basal Cell
(diagnosis, metabolism)
- Carcinoma, Skin Appendage
(diagnosis, metabolism)
- Carcinoma, Squamous Cell
(diagnosis, metabolism)
- Diagnosis, Differential
- Fluorescent Antibody Technique, Indirect
- Humans
- Sclerosis
(pathology)
- Skin
(metabolism, pathology)
- Skin Neoplasms
(diagnosis, metabolism)
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