RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection.

Abstract

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

• Authors: Oscar Cirioni, Roberto Ghiselli, Daniele Minardi, Fiorenza Orlando, Federico Mocchegiani, Carmela Silvestri, Giovanni Muzzonigro, Vittorio Saba, Giorgio Scalise, Naomi Balaban, Andrea Giacometti
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 51 Issue 12 Pg. 4518-20 (Dec 2007) ISSN: 0066-4804 [Print] United States
• PMID: 17875996 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Peptides
• RNA, Bacterial
• RNAIII, Staphylococcus aureus
• Teicoplanin

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Biofilms (drug effects, growth & development)
• Disease Models, Animal
• Female
• Peptides (pharmacology)
• RNA, Bacterial (antagonists & inhibitors)
• Rats
• Rats, Wistar
• Staphylococcal Infections (microbiology, prevention & control)
• Staphylococcus aureus (drug effects, genetics, growth & development)
• Stents (microbiology)
• Teicoplanin (pharmacology)
• Ureter (surgery)