Hypersplenism induced by splenic vein ligation.

Warm autoimmune hemolytic anemia (AIHA) is a rare clinical entity. It is usually caused by an IgG autoantibody directed against the red blood cell membrane that causes extravascular hemolysis predominantly in the spleen. As a result, disease states or procedures that result in hypersplenism would be expected to increase red cell destruction in patients with an underlying warm AIHA. We present the case of a patient with a previously undiagnosed warm AIHA, who developed worsening hemolysis after undergoing splenic vein ligation during a pancreaticoduodenectomy to remove a neuroendocrine tumor.
AuthorsBrian Garibaldi, Karen E King, Julie M Jaffe, Alison R Moliterno
JournalAmerican journal of hematology (Am J Hematol) Vol. 83 Issue 3 Pg. 242-4 (Mar 2008) ISSN: 0361-8609 [Print] United States
PMID17874452 (Publication Type: Case Reports, Journal Article)
Copyright(c) 2007 Wiley-Liss, Inc.
  • Anemia, Hemolytic, Autoimmune (blood, complications)
  • Blood Transfusion
  • Duodenum (surgery)
  • Hemolysis
  • Humans
  • Hypersplenism (surgery)
  • Male
  • Middle Aged
  • Pancreatectomy
  • Splenic Vein (surgery)
  • Treatment Outcome

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