Patients with either relapsed or refractory
T-cell acute lymphocytic leukemia (
T-ALL) are candidates for allogeneic
hematopoietic stem cell transplantation (allo-HSCT). Achieving complete remission (CR) in these patients is difficult but crucial for the success of allo-HSCT. In this study, we examined 6 relapsed or refractory
T-ALL patients. In the patient group, 4 were male and 2 were female, with ages ranging from 15 to 57 years (median=29 years). All 6 patients presented with the nonmature
T-ALL phenotype. Cytogenetically, only one had an i(7q) anomaly, whereas the remaining 5 cases had normal karyotypes. One of these patients had the MLL/AF9 fusion transcript, as shown by molecular study. After initial
remission-induction therapy, two patients achieved CR, one showed a partial remission, and all relapsed soon. The other 3 cases failed the
therapy. The
CAG regimen (
cytosine arabinoside 10 mg/m(2) subcutaneously every 12 hr, day 1-14;
aclarubicin 5-7 mg/m(2) intravenously daily, day 1-8; and concurrent use of
G-CSF 200 microg/m(2)/day subcutaneously) was devised originally for the treatment of relapsed
acute myelogenous leukemia. After CAG
therapy, all the
T-ALL patients in our study achieved CR, indicating that the
CAG regimen is beneficial to the treatment of relapsed or refractory
T-ALL. The efficacy of CR-induction in
T-ALL patients and the adverse effects of the
CAG regimen need to be further studied.