[An analysis of the possible mechanism of the ulcerostatic action of 1-ethoxysilatrane].

Abstract

Stimulating effect of 1-ethoxysilatrane on healing processes of experimental stomach ulcers was studied in rats. 1-ethoxysilatrane inhibited lipid peroxidation in blood and stomach wall tissues, interacted with artificial membranes, and affected the rate of mitochondrial respiration in liver. A hypothesis is put forward on the membranotropic effect of 1-ethoxysilatrane which underlies its ulcerostatic effect.

• Authors: M M Rasulov, I G Kuznetsov, L K Bartkova, S K Suslova, A A Belousov, M G Voronkov
• Journal: Izvestiia Akademii nauk SSSR. Seriia biologicheskaia (Izv Akad Nauk SSSR Biol) 1991 Jul-Aug Issue 4 Pg. 522-7 ISSN: 0002-3329 [Print] Russia (Federation)
• Vernacular Title: Analiz vozmozhnogo mekhanizma ul'tserostaticheskogo deĭstviia 1-étoksisilatrana.
• PMID: 1787228 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Acetates
• Anti-Ulcer Agents
• Bridged Bicyclo Compounds
• Bridged Bicyclo Compounds, Heterocyclic
• Lipid Bilayers
• Membrane Lipids
• Organosilicon Compounds
• 1-ethoxysilatrane
• Silicon

Topics

• Acetates
• Animals
• Anti-Ulcer Agents (pharmacology, therapeutic use)
• Bridged Bicyclo Compounds (pharmacology, therapeutic use)
• Bridged Bicyclo Compounds, Heterocyclic
• Drug Evaluation, Preclinical
• Lipid Bilayers
• Lipid Peroxidation (drug effects)
• Membrane Lipids
• Membrane Potentials (drug effects)
• Organosilicon Compounds
• Rats
• Silicon (pharmacology, therapeutic use)
• Stomach Ulcer (chemically induced, drug therapy, metabolism)
• Time Factors
• Wound Healing (drug effects)