[A study on developmental toxicity of vanadium pentoxide in NIH mice].

Abstract

There is no general agreement yet about the teratogenic effects or developmental toxicity of vanadium in animal studies. This is a report on developmental toxicity in NIH mice following injection of vanadium pentoxide (V2O5, 5 mg/kg body weight, i.p.) at different times of gestation (on days 1-5, 6-15, 7, 8, 9, 10, 11, 14-17 of gestation). No adverse effects of V2O5 on pre-implantation and implantation were noted, and neither were teratogenicity and premature birth. However, there was toxic effect on embryofetus. Increased frequency of resorption or fetal death on days 6-15, 7, 14-17 of gestation were observed. Delayed ossification of bones was noted on days 6-15, 8, 10, 14-17 of gestation. These results suggest that V2O5 may be a weak developmental toxicant but not a teratogen in NIH mice. In addition, this paper reports the developmental toxicity, especially teratogenicity of N, N'-methylene-bis (2-amino-1, 3, 4-thiadiazole) which was used as the positive control in NIH mice.

• Authors: T Zhang, X Gou, Z Yang
• Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao (Hua Xi Yi Ke Da Xue Xue Bao) Vol. 22 Issue 2 Pg. 192-5 (Jun 1991) ISSN: 0257-7712 [Print] China
• PMID: 1786959 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vanadium Compounds
• Vanadium
• vanadium pentoxide

Topics

• Animals
• Embryonic and Fetal Development (drug effects)
• Female
• Fetal Resorption (chemically induced)
• Mice
• Osteogenesis (drug effects)
• Pregnancy
• Vanadium (toxicity)
• Vanadium Compounds