Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: We identified 33 patients who underwent a total of 41 Mohs procedures. Average +/- SD lesion size was 509 +/- 699 mm(2). An average of 2.6 +/- 1.4 stages were done using Mohs micrographic surgery. Five procedures were terminated with positive margins, including 3 due to urethral involvement and 2 due to defect size. Of the tumors 26 were stage Tis, 4 were T1, 7 were T2 and 4 were T3. A total of 13 defects were reconstructed by primary repair or granulation, 4 were reconstructed by skin grafts and 25 were reconstructed by tissue flaps and urethroplasty. Followup data were available on 25 patients at a mean of 58 +/- 63 months. Eight patients (32%) had recurrence, which was managed by repeat Mohs micrographic surgery in 7 and by penectomy in 1. There were 2 cases of tumor progression, including 1 from T1 to T3 disease (meatal involvement) and 1 from T1 to inguinal lymph node involvement. Two patients died, of whom 1 had no evidence of penile cancer and 1 had metastatic disease. CONCLUSIONS:
Mohs micrographic surgery for low stage penile cancer results in a relatively high local recurrence rate. However, with repeat procedures and vigilant followup cancer specific and overall survival rates are excellent and progression rates are low.
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Authors | Alan W Shindel, Margaret W Mann, Ronan Y Lev, Roberta Sengelmann, Jeffrey Petersen, George J Hruza, Steven B Brandes |
Journal | The Journal of urology
(J Urol)
Vol. 178
Issue 5
Pg. 1980-5
(Nov 2007)
ISSN: 0022-5347 [Print] United States |
PMID | 17869306
(Publication Type: Journal Article)
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Topics |
- Biopsy
- Carcinoma in Situ
(mortality, pathology, surgery)
- Carcinoma, Verrucous
(mortality, pathology, surgery)
- Follow-Up Studies
- Humans
- Incidence
- Male
- Mohs Surgery
(methods)
- Neoplasm Recurrence, Local
(epidemiology, pathology)
- Neoplasm Staging
- Penile Neoplasms
(mortality, pathology, surgery)
- Retrospective Studies
- Survival Rate
- Time Factors
- Treatment Outcome
- United States
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