Abstract |
Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea. Kinetin (N(6)-furfuryladenine) is a plant cytokinin that reportedly helps restore skin barrier function and may be useful to ameliorate the signs and symptoms of rosacea. The purpose of this open-label study was to determine the tolerance and efficacy of twice-daily application of kinetin 0.1% lotion for improving the signs and symptoms of mild to moderate facial rosacea. Subjects applied kinetin 0.1% lotion twice daily to the face, with daily use of a sunscreen of sun protection factor 30. Subjects were evaluated at baseline and at 4-week intervals for 12 weeks to assess efficacy and tolerance. Results of this study suggest that kinetin 0.1% lotion is a well-tolerated moisturizing lotion option for subjects with mild to moderate inflammatory rosacea.
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Authors | J J Wu, G D Weinstein, G J Kricorian, T Kormeili, J L McCullough |
Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 32
Issue 6
Pg. 693-5
(Nov 2007)
ISSN: 0307-6938 [Print] England |
PMID | 17868391
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dermatologic Agents
- Emollients
- Kinetin
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Topics |
- Administration, Cutaneous
- Adult
- Aged
- Dermatologic Agents
(adverse effects, therapeutic use)
- Drug Administration Schedule
- Emollients
(therapeutic use)
- Female
- Follow-Up Studies
- Humans
- Kinetin
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Rosacea
(drug therapy, pathology)
- Severity of Illness Index
- Treatment Outcome
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