Abstract | AIMS: METHODS: The expression of LHRH-R was examined in surgically removed human specimens of primary tumours and metastases from 37 RCC, 19 melanomas and 17 NHLs. In addition, human tumour cell lines expressing LHRH receptors were transplanted into nude mice and anti-tumour efficacy and systemic toxicity of AN-207 and its cytotoxic radical AN-201 were compared in various experiments. RESULTS: Positive staining for LHRH receptors was found in all of the RCC (37/37) and the melanoma specimens (19/19) as well as in 100% (10/10) of the NHLs. In in vivo experiments AN-207 significantly inhibited tumour growth while the cytotoxic radical alone was ineffective. Furthermore, side effects were reduced with targeted therapy. CONCLUSIONS:
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Authors | T Gaiser, J Rüschoff, A V Schally, G Keller, J B Engel |
Journal | Verhandlungen der Deutschen Gesellschaft fur Pathologie
(Verh Dtsch Ges Pathol)
Vol. 90
Pg. 186-92
( 2006)
ISSN: 0070-4113 [Print] Germany |
Vernacular Title | Die Expression von LHRH-Rezeptoren im malignen Melanom, Nierenzellkarzinom und Non Hodgkin Lymphom--Bedeutung für eine neue rezeptorvermittelte Chemotherapie mit zytotoxischen LHRH-Analoga. |
PMID | 17867596
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Receptors, LHRH
- Doxorubicin
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Disease Models, Animal
- Doxorubicin
(therapeutic use)
- Humans
- Kidney Neoplasms
(drug therapy, genetics, pathology)
- Lymphoma, Non-Hodgkin
(drug therapy, genetics, pathology)
- Melanoma
(drug therapy, genetics, pathology)
- Neoplasm Metastasis
- Receptors, LHRH
(analysis, antagonists & inhibitors)
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