| Abstract | We retrospectively evaluated the efficacy of mycophenolate mofetil (MMF) in the treatment of steroid-resistant acute and chronic graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation. Thirteen patients, ten men and three women, consisted of 5 cases of acute myelogenous leukemia, 2 of acute lymphoblastic leukemia, 2 of chronic myelogenous leukemia, 2 of lymphoblastic lymphoma, and 1 case each of adult T-cell leukemia and peripheral T-cell lymphoma. The transfusions consisted of 5 peripheral blood, 7 bone marrow and 1 cord blood from 3 mothers, 4 siblings and 6 unrelated donors with conditioning treatments, including 8 total-body irradiation-based regimens, and 2 busulfan plus cyclophosphamide and 2 reduced-intensity regimens. GVHD prophylaxis included FK506 plus methotrexate (MTX) and/or antithymocyte globulin for 9 patients, and cyclosporine and MTX for 4 patients. All patients were treated with second-line MMF for steroid-refractory acute and/or chronic GVHD, and 11 patients improved. The adverse events were tolerable except for one patient in whom grade 3 neutropenia forced discontinuation of treatment. No case of non-relapse mortality occurred. We consider that MMF is beneficial and well tolerated for treatment of steroid-refractory GVHD. |
| Authors | Masaki Mori, Kazuo Muroi, Tomohiro Matsuyama, Satoko Oka, Yoko Ono, Chizuru Yamamoto, Mitsuyo Uesawa, Hiroshi Okabe, Haruko Matsu, Raine Tatara, Yuji Kikuchi, Shinichiro Fujiwara, Satoru Kikuchi, Kazuya Sato, Masuzu Ueda, Masaki Toshima, Katsutoshi Ozaki, Masaaki Takatoku, Tadashi Nagai, Keiya Ozawa
(Affiliation: Division of Hematology and Cell Therapy, Jichi Medical University Hospital.)
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| Journal | [Rinshō ketsueki] The Japanese journal of clinical hematology
(Rinsho Ketsueki)
Vol. 48
Issue 8
Pg. 624-31
(Aug 2007)
ISSN: 0485-1439 Japan |
| PMID | 17867298
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Immunosuppressive Agents
- mycophenolate mofetil
- Mycophenolic Acid
|
| Topics |
- Adolescent
- Adult
- Female
- Graft vs Host Disease
(drug therapy)
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Middle Aged
- Mycophenolic Acid
(analogs & derivatives, therapeutic use)
- Retrospective Studies
|
