Abstract |
Zinc, cupric, and cadmium ions, in that order of effectiveness, inhibited lysis of washed, rabbit erythrocytes by the toxic bacterial product aerolysin. Hemolysis induced by a variety of other lytic agents was also inhibited by Zn2+ in approximately the same concentration as that, 0.33 mM, needed to inhibit aerolysin-induced hemolysis. Zinc ions did not inhibit osmotic lysis. Inhibition requires the continues presence of Zn2+ and apparently involves a readily reversible binding of Zn2+ to the cell surface, which, it is postulated is accompanied by a reversible alteration in the state of the lipid bilayer.
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Authors | L S Avigad, A W Bernheimer |
Journal | Infection and immunity
(Infect Immun)
Vol. 13
Issue 5
Pg. 1378-81
(May 1976)
ISSN: 0019-9567 [Print] United States |
PMID | 178604
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Cations, Divalent
- Hemolysin Proteins
- Streptolysins
- Toxins, Biological
- Zinc
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Topics |
- Animals
- Binding Sites
- Cations, Divalent
- Clostridium perfringens
- Depression, Chemical
- Hemagglutination
(drug effects)
- Hemolysin Proteins
(pharmacology)
- Hemolysis
(drug effects)
- In Vitro Techniques
- Rabbits
- Staphylococcus
- Streptolysins
(pharmacology)
- Toxins, Biological
(pharmacology)
- Zinc
(pharmacology)
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