Abstract |
The objective of this study was to evaluate the effect of local photodynamic therapy ( PDT) with verteporfin on tumor growth inhibition of squamous cell carcinoma (SCC) in a murine model. SCC was implanted in 85 nude mice by subcutaneous injection of A-431 SCC cells. Treatment groups (10 mice/group) received an intra-tumoral injection of verteporfin dissolved in dimethyl sulfoxide ( DMSO) or 5% dextrose solution at a dose of 0.01 or 0.1mg/cm3. Controls received only solvent, or no injectate. All groups received identical light illumination (100J/cm2). Relative change in tumor volume (RCTV) at day 30 was compared between groups using the Wilcoxon rank sum test (P< 0.05). Local PDT with verteporfin at a dose of 0.1mg/cm3 resulted in significantly lower RCTV at day 30 compared to controls. Choice of solvent ( DMSO versus D5W) did not affect the results. Local PDT may be an effective adjunctive therapy for the treatment of periocular equine SCC.
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Authors | J Ota, E A Giuliano, L A Cohn, M R Lewis, C P Moore |
Journal | Veterinary journal (London, England : 1997)
(Vet J)
Vol. 176
Issue 2
Pg. 170-6
(May 2008)
ISSN: 1090-0233 [Print] England |
PMID | 17855133
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Photosensitizing Agents
- Porphyrins
- Verteporfin
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Topics |
- Animals
- Carcinoma, Squamous Cell
(drug therapy, pathology, veterinary)
- Eye Neoplasms
(drug therapy, pathology, veterinary)
- Female
- Histocytochemistry
- Horse Diseases
(drug therapy, pathology)
- Horses
- Humans
- Injections, Intralesional
- Mice
- Mice, Nude
- Photochemotherapy
(methods, veterinary)
- Photosensitizing Agents
(administration & dosage)
- Porphyrins
(administration & dosage)
- Random Allocation
- Specific Pathogen-Free Organisms
- Verteporfin
- Xenograft Model Antitumor Assays
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