Complement C4B protein in schizophrenia.

Abstract

Partial and/or complete deficiency of the complement protein C4 is associated with autoimmune and infectious diseases. Infectious or autoimmune processes may have a role in schizophrenia. Previous reports suggest abnormalities in the complement C4B isotype in schizophrenia and other mental disorders. We assessed C4A and C4B isotypes and serum C4B protein concentration in Armenian schizophrenic patients. Although there was no difference in frequency of C4BQ0, C4B serum protein level was significantly decreased in the schizophrenic patients compared with healthy controls.

• Authors: Karine R Mayilyan, Alister W Dodds, Anna S Boyajyan, Armen F Soghoyan, Robert B Sim
• Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (World J Biol Psychiatry) Vol. 9 Issue 3 Pg. 225-30 ( 2008) ISSN: 1562-2975 [Print] England
• PMID: 17853297 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Complement C4b

Topics

• Complement C4b (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Schizophrenia (metabolism, physiopathology)