| Abstract | INTRODUCTION: Khat leaves (mainly cathinone and cathine) have been chewed for centuries as stimulants. Hagigat (capsules of 200 mg cathinone) have been marketed in Israel as a natural stimulant and aphrodisiac. The consequences of illicit exposure to cathinone are reported. METHODS: Prospective observational study of calls to the Poison Center regarding exposure to Hagigat during the course of 10 months. Demographic and clinical data were abstracted from patients' records and telephone follow up was performed. RESULTS: Data of 34 consecutive patients aged 16-54 years were analyzed. The amount consumed was (1/2)-6 capsules (ingestion-32, sniffing-2). Main clinical manifestations were headache, vomiting, hypertension, nausea, tachycardia, dyspnea, chest pain, and myalgia. Main complications were myocardial ischemia (3), pulmonary edema (2), and intracerebral hemorrhage (1), all in young subjects. Treatment was supportive; one patient underwent neurosurgery. CONCLUSION: Exposure to illicitly synthesized cathinone is associated with serious cardiovascular and neurological toxicity, even in young subjects. |
| Authors | Yedidia Bentur, Anna Bloom-Krasik, Bianca Raikhlin-Eisenkraft
(Affiliation: Israel Poison Information Center, Rambam Health Care Campus, The Bruce Rappaport Faculty of Medicine, Haifa, Israel. d_bentur at rambam.health.gov.il)
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| Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 46
Issue 3
Pg. 206-10
(Mar 2008)
ISSN: 1556-3650 United States |
| PMID | 17852166
(Publication Type: Journal Article)
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| Chemical References |
- Alkaloids
- Central Nervous System Stimulants
- Street Drugs
- cathinone
|
| Topics |
- Adolescent
- Adult
- Alkaloids
(poisoning)
- Cardiovascular Diseases
(chemically induced)
- Central Nervous System Stimulants
(poisoning)
- Female
- Follow-Up Studies
- Humans
- Israel
- Male
- Mental Disorders
(chemically induced, psychology)
- Middle Aged
- Poison Control Centers
- Prospective Studies
- Respiratory Tract Diseases
(chemically induced)
- Street Drugs
(poisoning)
- Substance-Related Disorders
|
