There is still considerable controversy concerning the role of
androgen therapy for
hypoactive sexual desire disorder in females. Clinical trials have shown that exogenous
testosterone therapy improves arousability, sexual desire and fantasy, frequency of sexual activity and orgasm, and satisfaction and pleasure from the sexual act. We report our experience of 36-year-old fragile X carrier female presented to our department with low sex drive and subjectively poor arousal for the past 1 year. We decided to treat her with local
testosterone in a pump form (1% 5 g twice a week). She responded very well to the treatment, and in 3 weeks her libido and sexual functions improved dramatically. We decided to continue the same treatment for almost 1 year following up her free and total
testosterone, complete
lipid profiles, liver functions and complete blood picture every 3 months. During the whole course of treatment, she had mild facial
acne, which was resolved in 2 months after completing treatment with
testosterone. This is our first and only case of this syndrome with low sexual desire disorder treated with local
testosterone in a pump form. Based upon our 1 year follow-up, low-dose
testosterone is a safe and effective approach in treating
hypoactive sexual desire disorder in a fragile X carrier female, provided the patient is monitored every 3 months for blood counts,
lipid profiles, liver functions and free and total
testosterone levels.