| Abstract | We report a mixed intoxication with isopropyl alcohol and propanol-1 in a hospitalized patient who ingested, on two separate days, two 100 ml bottles of a topical antiseptic solution containing isopropyl alcohol and propanol-1. Eight hours after the second ingestion, plasma concentrations of isopropanol, propanol-1 and acetone were 37 mg/dL, <10 mg/dL, and 227 mg/dl, respectively. Despite a lack of severe toxicity, 4-methylpyrazole (fomepizole) was initiated. This case points out the need to limit access to alcohol-containing antiseptic solutions on wards where alcoholic and psychotic patients are hospitalized. |
| Authors | Benoit Blanchet, Antoine Charachon, Stéphanie Lukat, Estelle Huet, Anne Hulin, Alain Astier
(Affiliation: Laboratory of Pharmacology and Toxicology, CHU Henri Mondor, Créteil, France. benoit.blanchet at hmn.ap-hop-paris.fr)
|
| Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 45
Issue 6
Pg. 701-4
(Sep 2007)
ISSN: 1556-3650 United States |
| PMID | 17849246
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Anti-Infective Agents, Local
- Antidotes
- Drug Combinations
- Pyrazoles
- 2-Propanol
- 1-Propanol
- fomepizole
|
| Topics |
- 1-Propanol
(poisoning)
- 2-Propanol
(poisoning)
- Adult
- Anti-Infective Agents, Local
(poisoning)
- Antidotes
(administration & dosage, therapeutic use)
- Drug Combinations
- Female
- Humans
- Poisoning
(drug therapy)
- Pyrazoles
(administration & dosage, therapeutic use)
- Suicide, Attempted
(psychology)
- Treatment Outcome
|
