To address the need for minimally invasive treatment of unresectable
tumors, intratumoral
polymer implants have been developed to release a variety of chemotherapeutic agents for the locoregional
therapy of
cancer. These implants, also termed "
polymer millirods," were designed to provide optimal drug release kinetics to improve
drug delivery efficiency and antitumor efficacy when treating unresectable
tumors. Modeling of
drug transport properties in different tissue environments has provided theoretical insights on rational implant design, and several imaging techniques have been established to monitor the local
drug concentrations surrounding these implants both ex vivo and in vivo. Preliminary antitumor efficacy and
drug distribution studies in a rabbit liver
tumor model have shown that these implants can restrict
tumor growth in small animal
tumors (diameter < 1 cm). In the future, new approaches, such as three-dimensional (3-D)
drug distribution modeling and the use of multiple
drug-releasing implants, will be used to extend the efficacy of these implants in treating larger
tumors more similar to intractable human
tumors.