| Abstract | BACKGROUND: Optimal chemotherapy for advanced biliary tract cancer (BTC) is yet to be defined. We carried out this study to evaluate the efficacy and toxicity of combination chemotherapy with S-1 and cisplatin in metastatic or relapsed BTC. PATIENTS AND METHODS: Patients with pathologically proven BTC were eligible. The chemotherapy regimen consisted of S-1 (40 mg/m(2) p.o. b.i.d. from D1-14) and cisplatin (60 mg/m(2) on D1), repeated every 3 weeks. RESULTS: Fifty-one BTC patients (metastatic:relapsed = 37:14, Gall-bladder:intrahepatic bile ducts:extrahepatic bile ducts = 16:25:10) were enrolled from January 2005 to December 2006. Median age was 57 years (range, 31-71) and most patients had a good performance status. The overall response rate was 30% [95% confidence interval (CI), 17.3-42.7] and complete response was observed in two patients (4%), partial response in 13 (26%), stable disease in 21 (42%), and progressive disease in 9 (18%). With a median follow-up of 12.4 months, the median time to progression was 4.8 months (95% CI, 3.3-6.3) and median overall survival was 8.7 months (95% CI, 6.0-11.4). Major toxic effects were grade 3/4 neutropenia (8.9% of all cycles) and febrile neutropenia was observed in six cycles (2.7% of all cycles). CONCLUSION: Combination chemotherapy with S-1 and cisplatin was a moderately effective outpatient-based regimen in BTC patients. Toxic effects were moderate but manageable. |
| Authors | Y J Kim, S-A Im, H G Kim, S Y Oh, K W Lee, I S Choi, D Y Oh, S H Lee, J H Kim, D W Kim, T Y Kim, S W Kim, D S Heo, Y B Yoon, Y J Bang
(Affiliation: Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.)
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| Journal | Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
(Ann Oncol)
Vol. 19
Issue 1
Pg. 99-103
(Jan 2008)
ISSN: 1569-8041 England |
| PMID | 17846018
(Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Drug Combinations
- Pyridines
- gimeracil
- S 1 (combination)
- Cisplatin
- Tegafur
- Oxonic Acid
|
| Topics |
- Adenocarcinoma
(drug therapy, secondary)
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Biliary Tract Neoplasms
(drug therapy, pathology)
- Cisplatin
(administration & dosage, adverse effects)
- Disease Progression
- Disease-Free Survival
- Drug Combinations
- Female
- Humans
- Kaplan-Meiers Estimate
- Male
- Middle Aged
- Neutropenia
(chemically induced)
- Oxonic Acid
(administration & dosage, adverse effects)
- Pyridines
(administration & dosage, adverse effects)
- Salvage Therapy
- Survival Analysis
- Tegafur
(administration & dosage, adverse effects)
- Thrombocytopenia
(chemically induced)
|
