Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: autopsy case report and review of the literature.

Abstract

Epstein-Barr virus (EBV) associated smooth muscle tumors (SMTs) have been described in patients with acquired immune deficiency syndrome (AIDS) and, more recently, in association with immunosuppression after solid-organ transplantation. We present the autopsy findings of multiple leiomyosarcomas (LMSs) in a 24-year old man who died 18 months after undergoing orthotopic cardiac transplantation for idiopathic cardiomyopathy. The recognition of EBV-driven LMS developing in cardiac transplant recipients in multiple unusual sites is crucial for the management of these patients and should include complete surgical removal anti-viral therapy and modulation of immunosuppression.

• Authors: Samina Nur, Warren D Rosenblum, Uma Devi Katta, Humayun Islam, Kathy Brown, Gita Ramaswamy
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) Vol. 26 Issue 9 Pg. 944-52 (Sep 2007) ISSN: 1557-3117 [Electronic] United States
• PMID: 17845934 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Adult
• Epstein-Barr Virus Infections (complications)
• Heart Transplantation (immunology)
• Herpesvirus 4, Human
• Humans
• Immunosuppression Therapy (adverse effects)
• Leiomyosarcoma (immunology, pathology, virology)
• Male
• Neoplasms, Multiple Primary (immunology, pathology, virology)
• Smooth Muscle Tumor (immunology, pathology, virology)