Abstract |
Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p less than 0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, beta-CCP (p = 0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, beta-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 +/- 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.
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Authors | T J Kreeger, A S Levine, U S Seal, M Callahan, M Beckel |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 39
Issue 3
Pg. 559-61
(Jul 1991)
ISSN: 0091-3057 [Print] United States |
PMID | 1784584
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Carbolines
- beta-carboline-3-carboxylic acid ethyl ester
- propyl beta-carboline-3-carboxylate
- Diazepam
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Topics |
- Animals
- Carbolines
(pharmacology)
- Carnivora
(psychology)
- Diazepam
(pharmacology)
- Dose-Response Relationship, Drug
- Feeding Behavior
(drug effects)
- Female
- Male
- Satiation
(physiology)
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