| Abstract | OBJECTIVE: To study the expression of neutral endopeptidase (CD10) and motility-related protein-1 (CD9) in malignant melanoma and their clinical significance. METHODS: Immunohistochemical study for CD10 and CD9 using Streptavidin-biotin complex technique was carried out in 48 cases of primary cutaneous malignant melanoma (CMM), 23 cases of metastatic melanoma and 23 cases of benign nevus. RESULTS: The positivity rate of CD10 was highest in metastatic melanoma and lowest in benign nevus (P < 0.01). In contrast, the positivity rate of CD9 in metastatic melanoma was lower than that in CMM (P < 0.05). The expression of CD9 was inversely correlated with that of CD10 in malignant melanoma (CMM: r = -0.40, P = 0.005; metastatic MM: r = -0.44, P = 0.034). The expression of CD10 and CD9 in CMM also correlated with tumor histology, Clark's level of invasion and presence of nodal metastasis. A similar relationship was also observed for CD10 and CD9 expression in stromal fibroblasts of CMM (r = -0.43, P = 0.007). CONCLUSIONS: CD10 and CD9 expression correlates with the invasiveness and metastatic potential of malignant melanoma; both factors may demonstrate a counteracting effect. These two markers have potential implications in prognostic assessment of CMM. Stromal fibroblasts may also play an important role in the progression of CMM. |
| Authors | Yan Wu, Xiao-bing Zhang, Hou-jun Liu, Li-duan Zheng, Jia-wen Li, Yun Lin
(Affiliation: Department of Dermatology, The Affiliated Xiehe Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.)
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| Journal | Zhonghua bing li xue za zhi Chinese journal of pathology
(Zhonghua Bing Li Xue Za Zhi)
Vol. 36
Issue 7
Pg. 466-9
(Jul 2007)
ISSN: 0529-5807 China |
| PMID | 17845760
(Publication Type: English Abstract, Journal Article)
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