Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection.

Abstract

BACKGROUND:

Two receptor chains, IL-10RA and IL-10RB, are known to mediate the functions of interleukin-10 (IL-10), which has been shown to be involved in the progression of persistent hepatitis C virus (HCV) infection. Little information is available on the role of host genetic variation in IL-10 receptor genes and outcome of HCV infection. IL-22, an IL-10 homologue, shares the IL-10RB receptor chain with IL-10 and has antiviral properties. We investigated the possible role of polymorphisms in the IL-10RA and IL-22 genes in hepatitis C disease pathogenesis.

METHODS:

This study population consisted of 631 HCV patients, recruited from several hepatology clinics across Europe. We genotyped four single-nucleotide polymorphisms (SNPs) in the IL-10RA and six SNPs in the IL-22 gene by ligation detection reaction or restriction fragment length polymorphism. Outcome of HCV infection was assessed according to viral clearance, treatment response, severity of fibrosis and overall inflammation.

CONCLUSIONS:

Variation in IL-10RA appeared to be correlated with response to treatment and inflammation. Two SNPs in IL-22 affected treatment response and viral clearance respectively. We furthermore report on allele and haplotype frequencies and linkage disequilibrium for IL-10RA and IL-22. Our results indicate that genetic variation in these genes may play a modulatory role in the outcome of hepatitis C infection.

• Authors: Branwen J Hennig, Angela J Frodsham, Simon Hellier, Susanne Knapp, Leland J Yee, Mark Wright, Lyna Zhang, Howard C Thomas, Mark Thursz, Adrian V Hill
• Journal: Liver international : official journal of the International Association for the Study of the Liver (Liver Int) Vol. 27 Issue 8 Pg. 1134-43 (Oct 2007) ISSN: 1478-3223 [Print] United States
• PMID: 17845543 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Interleukin-10 Receptor alpha Subunit
• Interleukins
• interleukin-22

Topics

• Adult
• Antiviral Agents (therapeutic use)
• Case-Control Studies
• DNA Mutational Analysis
• Europe
• Female
• Gene Frequency
• Haplotypes
• Hepatitis C (drug therapy, genetics)
• Humans
• Interleukin-10 Receptor alpha Subunit (genetics)
• Interleukins (genetics)
• Linkage Disequilibrium
• Male
• Polymorphism, Single Nucleotide
• Treatment Outcome