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Alteration in progression of murine autoimmune disease by treatment with a novel immunomodulator, SM-8849.

Abstract
The effects of SM-8849 on the development of autoimmune disease in MRL/Mp-1pr/1pr mice were examined. SM-8849 improved survival as well as renal disease, restored the deficits in splenic cell responsiveness to stimulation by mitogens or conventional antigens, and prevented lymphadenopathy and splenomegaly coincident with a decrease in the number of Thy-1+/Lyt-2-/L3T4- cells. SM-8849 also suppressed the production of the B-cell differentiation factor, possibly with a resulting preferential reduction of autoantibodies. In addition, SM-8849 depressed the production of hydrogen peroxide from macrophages. These results suggest that the administration of SM-8849 to a subject with autoimmune diseases can induce immunological improvements with possible clinical effectiveness.
AuthorsF Nishikaku, Y Koga
JournalInternational journal of immunopharmacology (Int J Immunopharmacol) Vol. 13 Issue 5 Pg. 445-54 ( 1991) ISSN: 0192-0561 [Print] England
PMID1783457 (Publication Type: Journal Article)
Chemical References
  • Autoantibodies
  • Biphenyl Compounds
  • Interleukin-6
  • Thiazoles
  • 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole
  • Hydrogen Peroxide
Topics
  • Animals
  • Autoantibodies (immunology)
  • Autoimmune Diseases (drug therapy)
  • Biphenyl Compounds (therapeutic use)
  • Glomerulonephritis (drug therapy)
  • Hydrogen Peroxide (metabolism)
  • Hypergammaglobulinemia (drug therapy)
  • In Vitro Techniques
  • Interleukin-6 (metabolism)
  • Lymphatic Diseases (drug therapy)
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred Strains
  • Spleen (immunology)
  • Splenomegaly (drug therapy)
  • T-Lymphocytes (immunology)
  • Thiazoles (therapeutic use)

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