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Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins.

Abstract
The polymorphisms of the B subunit of coagulation factor XIII (F13B), plasminogen (PLG), complement C6, C7, factor B (BF) and factor I (IF) were studied among 21 unrelated Japanese patients with primary varicose veins (PVV) by isoelectric focusing followed by immunoblotting. The allele frequencies for F13B*2 and IF*A in PVV patients were significantly higher (F13B*2, p = 0.0047; IF*A, p = 0.0006) than those in healthy controls (n = 60). Significant associations of F13B 2 allotype [p = 0.0220, relative risk (RR) = 13.9] and IF A allotype (p = 0.0006, RR = 10.0) with PVV were observed; however, no significant association of PLG, C6, C7 or BF allotype with the disease was found.
AuthorsK Mizutani, H Nishimukai, T Yasugi, K Iwahashi, K Tsunekawa, T Shinomiya
JournalHuman heredity (Hum Hered) Vol. 41 Issue 4 Pg. 270-5 ( 1991) ISSN: 0001-5652 [Print] Switzerland
PMID1783414 (Publication Type: Journal Article)
Chemical References
  • Blood Proteins
  • Plasminogen
  • Complement System Proteins
  • Factor XIII
  • factor XIIIb
Topics
  • Adult
  • Alleles
  • Blood Proteins (genetics)
  • Complement System Proteins (genetics)
  • Factor XIII (genetics)
  • Female
  • Gene Frequency (genetics)
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Phenotype
  • Plasminogen (genetics)
  • Polymorphism, Genetic (genetics)
  • Varicose Veins (blood, genetics)

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