Abstract |
The polymorphisms of the B subunit of coagulation factor XIII (F13B), plasminogen (PLG), complement C6, C7, factor B (BF) and factor I (IF) were studied among 21 unrelated Japanese patients with primary varicose veins (PVV) by isoelectric focusing followed by immunoblotting. The allele frequencies for F13B*2 and IF*A in PVV patients were significantly higher (F13B*2, p = 0.0047; IF*A, p = 0.0006) than those in healthy controls (n = 60). Significant associations of F13B 2 allotype [p = 0.0220, relative risk (RR) = 13.9] and IF A allotype (p = 0.0006, RR = 10.0) with PVV were observed; however, no significant association of PLG, C6, C7 or BF allotype with the disease was found.
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Authors | K Mizutani, H Nishimukai, T Yasugi, K Iwahashi, K Tsunekawa, T Shinomiya |
Journal | Human heredity
(Hum Hered)
Vol. 41
Issue 4
Pg. 270-5
( 1991)
ISSN: 0001-5652 [Print] Switzerland |
PMID | 1783414
(Publication Type: Journal Article)
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Chemical References |
- Blood Proteins
- Plasminogen
- Complement System Proteins
- Factor XIII
- factor XIIIb
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Topics |
- Adult
- Alleles
- Blood Proteins
(genetics)
- Complement System Proteins
(genetics)
- Factor XIII
(genetics)
- Female
- Gene Frequency
(genetics)
- Humans
- Japan
- Male
- Middle Aged
- Phenotype
- Plasminogen
(genetics)
- Polymorphism, Genetic
(genetics)
- Varicose Veins
(blood, genetics)
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